The Yeast Surveillance Network is a comprehensive, long-term system for the epidemiological and microbiological surveillance of yeast bloodstream infections in the Île-de-France region. We present the results regarding candidemia caused by the most common species in adults. Between October 1, 2002, and September 30, 2010, 2,571 isolates were identified during a first episode of candidemia in 2,507 patients. The majority were men (60%) with a mean age of 60 years, 48% of whom were hospitalized in intensive care units. The six most common species were C. albicans (54.1% of infections), C. glabrata (18%), C. parapsilosis (11.1%), C. tropicalis (9%), C. krusei (2.8%), and C. kefyr (1.7%); 3.3% of candidemias were mixed (involving multiple fungal species). Antifungal susceptibility profiles did not differ from expected results for each species and did not change significantly over time. Species distribution varied according to age, type of underlying condition, hospital department, and prior antifungal exposure before the onset of fungemia. The 30-day crude mortality rate was 40.6%, with 58% of deaths occurring in the first week. Candidemia remains a common hospital-acquired infection associated with high mortality, which remained unchanged over the study period. (R.A.)