Objectives: The cost of intimate partner violence and its impact on children (IPV-C) was calculated for the year 2012 in France. As in other studies, this type of calculation has helped to establish interpersonal violence as a public health issue over the past two decades. We discuss the methodology, results, and potential contributions to health policies. Materials and methods: The study is based on 1) administrative data; 2) general population surveys (prevalence and incidence of the phenomena, substantiation of causal links between experienced violence and health); 3) specific studies (general population or clinical data); 4) qualitative supplements gathered from experts to fill data gaps. For the monetary valuation of VSCE, the “statistical value of life” is used, based on the estimate conducted in France in 2013. Results: The total cost of domestic violence is estimated at 3.6 billion euros in 2012, of which 21.5% are direct costs (medical or otherwise), 66.8% are indirect costs, and 11.7% are costs borne by children. Both for the expenditures attributable to domestic violence (opportunity costs) and for the lost income they generate, their costs are overwhelmingly determined by the victimization of women within the couple. Discussion: The increase in the cost of VSCE since the first French study can be explained by the availability of new data and opens up discussions regarding certain assumptions made in each of the studies conducted regarding specific cost items. It is primarily explained by an increase in willingness to pay: as the “value of statistical life” has risen, it has increased the volume and share of indirect costs. Quantitative data are lacking, particularly for children. New qualitative data would also allow for a better interpretation of the rare and statistically atypical victimization of men. Conclusion: The cost calculation confirms the considerable burden of VSCE within a “burden of disease” framework. The data remain incomplete, and the operationalization of the “cost” instrument in health policies remains unfinished.