Bringing together employment professionals, public health researchers, and economists to address the issue of youth health within the Mission Locale framework was a three-year initiative led by the Mission Locale de Sénart, Inserm, and Crest. The PresaJe project was carried out amid its share of difficulties and pleasant surprises, with a common goal—youth health—but differing approaches and cultures, and a unique research context: support for employment integration. This collaboration was therefore not a natural fit, but a deliberate choice given the importance of the issue at hand, and it proved beneficial to all stakeholders.