Under the auspices of the Network for the Reporting, Investigation, and Surveillance of Nosocomial Infections, and in collaboration with the Study Group on Healthcare Workers’ Risk of Exposure to Infectious Agents, methods for monitoring blood-exposure incidents (BEIs) have been standardized and supported by a national network since 2002. All BSE incidents reported to the occupational physician from January 1 to December 31, 2010, are documented on a voluntary, anonymous, and standardized basis. In 2010, 17,039 BSE incidents were recorded, the majority of which were reported by paramedical staff. Eight out of ten documented AES are percutaneous injuries, primarily caused by needle sticks. After eight years of the network’s operation and by comparing data from 2004 and 2010, we can estimate that the number of AES has been reduced by just under a quarter in France between these two periods across all participating facilities. The collected data reflect the growing proportion of safety equipment ordered by facilities, regardless of the medical device in question, with a trend toward making more procedures safer over the years. This monitoring confirms the value of safety equipment, the use of which appears significantly associated with a lower risk of accidents per procedure. Overall, while a downward trend in accident incidence has been observed over time regardless of the equipment used—illustrating the positive impact of the training and information campaigns conducted year after year—the use of safety equipment further reduces this residual risk. (R.A.)