The surveillance of healthcare-associated infections (HAIs) is a priority in intensive care, a high-risk setting due to patients’ critical condition and their exposure to invasive devices. Since 2004, the national REA-Raisin surveillance program, coordinated by the Network for Alert, Investigation, and Surveillance of HAI, has targeted infections associated with invasive devices in adult intensive care units for which a prevention strategy is essential: pneumonia (PNE), colonization, infection, or bacteremia (COL/ILC/BLC) associated with central venous catheters (CVC), and bacteremia (BAC). Since 2015, participating units have been collecting data continuously from January through December (compared to 6 months previously) for all patients hospitalized for more than 2 days. From January to December 2016, 200 departments included 67,899 patients (mean age: 64.3 years), hospitalized for an average of 11.0 days, of whom 70.5% were admitted to medical wards, 17.5% to emergency surgery, and 12.0% to elective surgery; 7.7% of patients were trauma patients, 15.3% were immunocompromised, and 57.2% received antibiotic treatment upon admission. The mean IGS II score was 46.0, and the in-department mortality rate was 17.2%. Exposure to invasive devices is common: intubation (61.2%), central venous catheter (64.3%), and urinary catheter (85.8%). Among the 67,899 patients, 10.35% developed at least one monitored infection. The most frequently isolated microorganisms are P. aeruginosa (19.9%), S. aureus (13.5%), and S. epidermidis (12.1%). Since 2004, antibiotic resistance has been decreasing for S. aureus strains (15.2% MRSA in 2016). Resistance remains high for ESBL-producing E. coli (16.8% of ESBL-producing strains, with 1.8% resistant to imipenem), but appears to have stabilized in recent years. Incidence rates are 15.22 PNE per 1,000 intubation-days, 3.39 BAC per 1,000 hospital-days, 0.76 ILC, and 0.55 BLC per 1,000 CVC-days. These rates vary significantly from one department to another depending on patient characteristics. Over the past five years (2012 to 2016) across the entire network, certain risk factors have changed (increase in IGS II, fewer trauma patients and fewer patients receiving antibiotic therapy on admission, fewer elective and emergency surgeries), and exposure rates to invasive devices have decreased. A decrease in incidence rates per 1,000 days of exposure was observed: significant for BLC (-19.1%), non-significant for BAC (-2.3%), and ILC (-3.8%). Multivariate analysis reveals a non-significant decrease in 2016 in PNE associated with intubation (adjusted OR: 0.95; 95% CI: 0.89–1.00). However, it confirms the significant decrease in BLC (adjusted OR: 0.73; 95% CI: 0.60–0.90), which is linked to improvements in professional practices associated with invasive procedures in intensive care. With participation representing 45.6% of intensive care beds in France, the REA-Raisin data serve as a national benchmark for better understanding adverse events in intensive care and enable participating departments to compare, evaluate, and guide their prevention efforts.