In November 2014, French public health authorities renewed the recommendation to target for vaccination against invasive meningococcal disease men who have sex with men (MSM) and all individuals e25 years attending social venues associated with the gay community. This policy was extended beyond the Paris region as a reaction to the continuing spread of serogroup C isolates belonging to a new lineage within clonal complex cc11 since the recommendation was first issued in July 2013. In this report, we describe, based on combined epidemiological surveillance data and genetic typing of serogroup C meningococcal isolates, the spread of a specific invasive strain of meningococcus C (MenC) in the Paris region that had started as an outbreak among men who have sex with men (MSM) in June 2013.