The issue’s main feature focuses on perinatal care in Réunion and Mayotte. It outlines the historical and cultural context and analyzes living conditions as well as social and environmental determinants. It then examines the local situation regarding perinatal care, including examples of programs aimed at improving maternal and child health and preventing risks. In Réunion: prevention of fetal alcohol syndrome, therapeutic education to prevent gestational diabetes among pregnant women, and prevention of unintended pregnancies, including among adolescents. In Mayotte: a mobile consultation truck for pregnant women—cared for by a midwife and a social worker; a TV series to combat misconceptions about sexuality; professional training through Perinatal Health Days.