Key points: - Prevalence rates remained stable over the 2001–2003 period: 0.60 per 104 new donors for HIV, 8.0 per 104 for HCV, 1.8 per 104 for HBsAg, and 0.56 per 104 for HTLV. - Incidence rates for HIV and HBV (1.0 per 105 person-years) were three times higher than that of HCV (0.35 per 105 person-years) over the 2001–2003 period and eleven times higher than that of HTLV (0.09 per 105 person-years). - Between 1992 and 2003, HCV and HBV incidence rates decreased by a factor of 9 and 6, respectively. For HIV, rates decreased through 1996 and then stabilized. - Very low residual risk of transmitting a viral infection through transfusion: 1 in 315,000 donations for HIV, 1 in 10,000,000 donations for HCV, and 1 in 640,000 donations for HBV over the 2001–2003 period. - Limited benefit of viral genomic screening: over the first 30 months, it identified 2 donations infected with HIV and 3 donations infected with HCV. (R.A.)