Since 2008, the national organized colorectal cancer screening program has been expanded to cover the entire French territory. It targets men and women aged 50 to 74, who are invited every two years to take a guaiac test to detect occult blood in the stool. If the result is positive, a colonoscopy must be performed. During the 2008–2009 period, 46 departments conducted a full screening campaign. The results of the program evaluation carried out by the InVS are presented for these departments. Participation was 34.3%, with nearly three million people undergoing a screening test during this period. The percentage of positive tests was 2.8%, or 3.3% among men and 2.4% among women. The rate of colonoscopies performed following a positive test was 88%, with high-quality examinations, as 97% of colonoscopies were complete. Among men, colonoscopies performed following a positive test led to the diagnosis of an adenoma in 40.1% of cases and cancer in 9.0% of cases, based on the most severe lesion, while 36.8% of results were normal. Among women, 25.7% of colonoscopies led to a diagnosis of adenoma and 5.8% to a diagnosis of cancer. The result was normal for 55.9% of colonoscopies. Overall, colorectal cancer was diagnosed in 7.5% of individuals who underwent a colonoscopy following a positive test. The detection rate for advanced adenomas among screened individuals was 7.1 per 1,000 for men and 3.0 per 1,000 for women, with significant regional disparities. The detection rate for colorectal cancers also showed marked regional disparities, with an average rate of 2.6 per 1,000 ranging from 1.3 to 5.8 per 1,000 for men and an average rate of 1.2 per 1,000 ranging from 0.6 to 2.3 per 1,000 for women. A description of the colorectal cancers detected could only be provided for 21 departments, in which 1,441 invasive cancers were diagnosed, of which 43% were stage I, 23% stage II, 25% stage III, and 9% stage IV. This first evaluation since the program’s nationwide rollout provides an overview of organized colorectal cancer screening in France and highlights certain shortcomings, particularly regarding participation and data quality. Future evaluations will allow for an analysis of changes in these indicators.