The ATB-Raisin antibiotic consumption monitoring system contributes to the appropriate use of antibiotics. Its objectives are to enable each healthcare facility (HCF) to describe and analyze its antibiotic consumption and to compare these figures with bacterial resistance data by benchmarking against a comparable group of HCFs. Systemic ATBs in class J01 of the Anatomical Therapeutic Chemical (ATC) classification, rifampicin, oral imidazoles, and fidaxomicin, as well as systemic antifungals in class J02 (optional component), administered during inpatient stays, were expressed in terms of defined daily doses (DDD) and reported according to national and World Health Organization recommendations (ATC-DDD system, 2015). Resistance data were collected for seven bacteria/antibiotic pairs to enable each healthcare facility to assess its situation regarding selection pressure, on the one hand, and the clinical context contributing to the use of certain antibiotics, on the other. The 1,447 participating healthcare facilities in 2015 accounted for 69% of hospital days and had consumed 383 DDJ per 1,000 hospital days (HD). The most commonly used antibiotics were the amoxicillin-clavulanic acid combination (30%), amoxicillin (18%), and ceftriaxone (6%). Antibiotic consumption ranged from 60 DDD/1,000 HD in psychiatric hospitals to 697 in military teaching hospitals. Variations were observed across different specialties, ranging from 61 DDD/1,000 patient-days in psychiatry to 1,522 in intensive care. In the 542 healthcare facilities that participated every year since 2009, consumption increased most significantly between 2009 and 2012. After a period of stability (2012–2013) and a decline (-2.1% between 2013 and 2014), the 0.9% increase between 2014 and 2015 resulted in a 2.7% increase in consumption over the period (an increase that was not statistically significant). Resistance data were consistent with those from specific networks. Antifungal consumption was higher in hematology (275 DDD/1,000 patient-days) than in intensive care (147 DDD/1,000 patient-days). Network-based surveillance enables each healthcare facility to analyze its own situation, exchange information on practices and organizational structures, and track evolving trends. The analysis of antibiotic consumption should be supplemented by an evaluation of practices and the monitoring of indicators reflecting the quality of prescribing.