Objective: Smoking is a major cause of disease, associated with a significant public health impact on the health of populations. Our objective was to update the estimate of tobacco-attributable deaths using the latest French mortality data (metropolitan France) and the most recent parameters for calculating attributable fractions. Methods: Estimates were calculated using the method developed by Peto et al. and modified by Parkin, which combines mortality data, lung cancer death rates, and adjusted relative risks of death associated with smoking. These parameters were extracted from the most recent literature sources. Results: In 2013, the most recent year for which mortality data is available, we estimated that more than 73,000 deaths were attributable to smoking, corresponding to approximately 13% of deaths recorded in mainland France that same year. Between 2000 and 2013, while the number of deaths attributable to tobacco declined slightly among men, it doubled among women, rising from approximately 8,000 deaths in 2000 (3.1% of all deaths among women) to more than 17,000 deaths in 2013 (6.3% of all deaths). Discussion: With one of the highest prevalences of regular smokers among industrialized countries, tobacco use is the leading cause of preventable death in France. The trend of a very sharp increase in tobacco-related deaths observed among women is concerning for the future; it is essential to effectively implement public health measures to reverse this trend.