Key points: - Continued participation in Rena-VHC by 163 laboratories (8.4% of laboratories performing HCV serology tests in France) during the 2000–2003 period; - A 33% increase in the total number of anti-HCV serology tests performed (screening tests and confirmatory tests) from 2000 to 2003; - A 22% decrease in the number of people confirmed to be HCV-positive from 2000 to 2003. (R.A.)