Introduction: The initial results of the fifth round of the ESPAD (European School Survey Project on Alcohol and Other Drugs) survey, conducted among 6,642 French high school students, focus in particular on cigarette and shisha use among high school students in 2015. These findings provide an opportunity to examine changes in perceptions of tobacco accessibility in relation to measures prohibiting sales to minors. The 2015 survey also provides, for the first time, data on e-cigarette use among high school students. Methods: The ESPAD survey is a quadrennial school-based survey; its most recent round was conducted in 426 classes at public and private secondary schools in metropolitan France and, for the first time, in the overseas departments, between April and June 2015. Conducted at the European level, this self-administered survey was carried out simultaneously and using the same methodology in 35 countries. In France, it is led by the French Monitoring Center for Drugs and Drug Addiction, in partnership with the Ministries of National Education and Agriculture. Results: In 2015, nearly two-thirds of high school students (61%) reported having smoked at least one cigarette in their lifetime. This level of experimentation is significantly lower than in 2011 (70%). The same is true for daily smoking, which is once again on the decline, with 23% of high school students smoking in 2015 compared to 31% in 2011. Furthermore, nearly half of high school students (48%) had already used a hookah, and 7% had done so without ever having smoked a cigarette. Daily smokers perceived tobacco as much more accessible in 2015 than in 2011. This finding holds true for both adult smokers (+11 percentage points) and minors (+7 percentage points). A very large majority of daily smokers, whether minors or adults, reported regularly purchasing their cigarettes from a tobacco shop. Finally, the survey reveals that 40% of high school students reported in 2015 that they had already tried an e-cigarette and that one in ten students had used one within the past month.